Loss of Dickkopf-1 Restores Neurogenesis in Old Age and Counteracts Cognitive Decline
نویسندگان
چکیده
منابع مشابه
Loss of Dickkopf-1 restores neurogenesis in old age and counteracts cognitive decline.
Memory impairment has been associated with age-related decline in adult hippocampal neurogenesis. Although Notch, bone morphogenetic protein, and Wnt signaling pathways are known to regulate multiple aspects of adult neural stem cell function, the molecular basis of declining neurogenesis in the aging hippocampus remains unknown. Here, we show that expression of the Wnt antagonist Dickkopf-1 (D...
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ژورنال
عنوان ژورنال: Cell Stem Cell
سال: 2013
ISSN: 1934-5909
DOI: 10.1016/j.stem.2012.11.010